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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIAS1
All Species:
20
Human Site:
S468
Identified Species:
44
UniProt:
O75925
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75925
NP_057250.1
651
71836
S468
D
L
T
I
D
S
S
S
D
E
E
E
E
E
P
Chimpanzee
Pan troglodytes
XP_523109
766
83908
S583
D
L
T
I
D
S
S
S
D
E
E
E
E
E
P
Rhesus Macaque
Macaca mulatta
XP_001082800
642
70843
D460
L
T
I
D
S
S
S
D
E
E
E
E
E
P
S
Dog
Lupus familis
XP_535524
651
71773
S468
D
L
T
I
D
S
S
S
D
E
E
E
E
E
P
Cat
Felis silvestris
Mouse
Mus musculus
O88907
651
71599
S468
D
L
T
I
D
S
S
S
D
E
E
E
E
E
P
Rat
Rattus norvegicus
O70260
628
68345
E446
S
E
N
K
K
R
V
E
V
I
D
L
T
I
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516107
756
82793
S567
D
L
T
I
D
S
S
S
E
E
E
E
E
E
E
Chicken
Gallus gallus
NP_001026627
564
62782
P382
P
V
C
D
K
K
A
P
Y
E
H
L
I
I
D
Frog
Xenopus laevis
NP_001079161
649
71676
S467
I
D
L
T
I
D
S
S
S
D
E
E
E
E
E
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q94361
793
89556
L561
A
D
D
D
I
I
T
L
S
D
D
D
D
E
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q680Q4
884
97015
P496
Q
E
G
Y
S
D
G
P
A
P
L
K
L
G
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.9
98.6
99.6
N.A.
98
58.6
N.A.
82.2
82.9
87
N.A.
N.A.
N.A.
N.A.
24
N.A.
Protein Similarity:
100
84.9
98.6
99.8
N.A.
98.7
72
N.A.
84.2
85
94.3
N.A.
N.A.
N.A.
N.A.
40.9
N.A.
P-Site Identity:
100
100
40
100
N.A.
100
0
N.A.
86.6
6.6
40
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
46.6
100
N.A.
100
6.6
N.A.
93.3
20
46.6
N.A.
N.A.
N.A.
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
35.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
10
0
10
0
0
0
0
0
0
% A
% Cys:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
46
19
10
28
46
19
0
10
37
19
19
10
10
0
10
% D
% Glu:
0
19
0
0
0
0
0
10
19
64
64
64
64
64
37
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
0
0
0
10
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% H
% Ile:
10
0
10
46
19
10
0
0
0
10
0
0
10
19
10
% I
% Lys:
0
0
0
10
19
10
0
0
0
0
0
10
0
0
0
% K
% Leu:
10
46
10
0
0
0
0
10
0
0
10
19
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
19
0
10
0
0
0
10
37
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
0
0
19
55
64
55
19
0
0
0
0
0
10
% S
% Thr:
0
10
46
10
0
0
10
0
0
0
0
0
10
0
0
% T
% Val:
0
10
0
0
0
0
10
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _